Could Cancer Initiate From Bone Marrow Progenitors?

Abstract background: defining cancer stem cells and their origins is of much controversy, and constitutes a challenged knockout for cell targeting- anticancer drugs. herein, we put forward a hypothetic model for cancer stem cells initiation from bone marrow stem cells. these later, will differentiate into an ancestral progenitor that activates a memorial program – the black box cassette- that is responsible of abnormal neo-organogenesis in the form of tumors and metastases. to approve this model, we assume that characterizing and investigating the most primitive forms of the bone marrow progenitors is required; both inside their niche and in circulation of cancer patients.