gastric cancer: correlation of histologic type with commonly used prognostic variables

Background: gastric cancer is one of the most common cancers among iranian men and women. objectives: the aim here was to investigate different histopathologic types and features of this cancer in association with selected prognostic variables. methods: a retrospective cross-sectional study was performed to reevaluate the pathologic samples of 100 cases of gastric cancer referred to shohadaye tajrish hospital, tehran, iran from 2017 to 2022. results: we evaluated 100 cases of gastric cancer in this study. they had a mean age of 62.4 ± 13.44 years old (range 28 - 84 years) and were mostly men (n = 66, 66 %). on histopathologic evaluation, tubular carcinoma was the most common type (n = 45, 45%). we found a statistically significant correlation between the histologic type and perineural invasion (p-value = 0.024), lymphovascular invasion (p-value < 0.001), tumoral involvement of surgical margin (p-value = 0.012 ), infiltration depth of the primary tumor (pt) (p-value = 0.049) , number of metastatic lymph nodes (pn) (p-value = < 0.001) , tumor location in the antrum (p-value=0.033) and body (p-value = 0.013) , and tumor size (p-value = 0.002 and p-value = 0.031 in small and large size groups respectively). conclusions: according to the findings, histologic type of gastric cancer correlates with perineural invasion, lymphovascular invasion, tumoral involvement of the surgical margin, pt, pn, and tumor location and size.