prevalence of dna mismatch repair deficiency in endometrial cancer using immunohistochemistry

Background: endometrial cancer (ec) is known as the most common malignancy of the female reproductive system, suggested to be associated with hereditary nonpolyposis colorectal cancer (hnpcc) or lynch syndrome (ls). objectives: therefore, the aim of the present study was to screen for ls in patients with ec using immunohistochemistry (ihc). methods: in this retrospective cross-sectional study, the patients with ec, referred to qaem hospital, mashhad, iran, from 2015 - 2019, were enrolled. paraffin-embedded tissue blocks were then examined via ihc for the expression of four mismatch repair (mmr) proteins, including mlh1, msh2, msh6, andpms2. the demographic and tumor-related data were also extracted from medical records and pathology reports. the data were consequently analyzed at the significance level of p < 0.05. results: a total number of 100 patients with ec were evaluated using ihc, and 12 (12%) cases were found suspected. as well, no significant relationship was observed between ls and age, tumor site, tumor histology, tumor size, tumor grade, tumor-infiltrating lymphocytes (tils), and a family/personal history of malignancies. conclusions: the prevalence of ls based on the ihc expression of the mmr proteins (mlh1, msh2, msh6, and pms2) was 12% in the patients with ec. there was also no significant relationship between the cases suspected and the demographic and tumor-related data.