brain cancer treatment; a systematic review

Context: one of the most common aggressive and primary brain tumors is glioma. the majority of diagnoses are referred to high-grade malignant glioblastoma, which carries the worst prognosis. still, treatment of brain tumors remains a big challenge for clinicians. this study was designed to investigate the efficacy of gene therapy in the treatment of brain cancer. methods: studies use genes as a therapeutic agent in brain cancer treatment even alone or in combination with other treatment methods. full-text papers, which met the inclusion criteria, were independently assessed by two reviewers. disagreements were resolved by consultation with a third reviewer. results: statistical analysis showed that 50% of the papers used a virus, 36% used polymers, and 14% used cells as carriers to transfect the genes as a therapeutic agent in brain tumor models. data showed that the estimated size of the brain tumor was reduced by using co-treatment of the gene with one of the conventional therapies. conclusions: according to the results, co-treatment of the gene with conventional therapies could be more effective than the monotherapy methods.