association study of rs2987983 polymorphism in the promoter region of esr2 gene and susceptibility to nodular thyroid inwomen of markazi province, iran

Background: the risk of thyroid disease has been increased during recent years; more than 200 million people are suffering from various types of thyroid diseases. the rate of thyroid nodules in women is 4 times more than that of men. epidemiological findings and experimental evidence of thyroid lesions suggest that sex hormones, especially estrogen, may affect this gland and its neoplasms.objectives: considering the prevalence of benign and malignant thyroid disease in women, we investigated the association between rs2987983 polymorphism in the estrogen receptor beta gene and nodular thyroid disease.methods: in this case-control study, 146 patients with thyroid nodules from amir- almomenin hospital in arak were compared with 151 healthy individuals. the diagnosis was performed by ultrasonography and confirmed by an endocrinologist. after dnaextraction, genotyping was performed with t-arms pcr. finally, statistical analysis was carried out.results: the frequencies of aa, ag, and gg genotypes in the case group were 48 (32.9%), 83 (56.8%), and 15 (10.3%), respectively. thesevalues in the control group were 64 (42.4%), 64 (42.4%), and 23 (15.2%), respectively. overall, a statistically significant association (p =0.042, χ² = 6.3, df = 2) was observed between rs2987983 polymorphism and thyroid nodules.conclusions: considering the significant association between rs2987983 polymorphism and thyroid nodules, it can be suggested that the mentioned polymorphism may be used as a diagnostic biomarker. because this polymorphism is in the promoter regionof the gene, it probably alters gene expression levels.