invasive growth hormone producing pituitary adenoma with lymphocytic infiltration: a case report and literature review

Introduction: we have presented a rare case of growth hormone (gh) producing pituitary adenoma with lymphocytic infiltration and brain parenchyma invasion. case presentation: a 37-year-old woman has presented with complaints of headache, amenorrhea and acromegalic features. her laboratory studies showed markedly elevated levels of insulin-like growth factor 1 (igf-1), and low levels of follicle stimulating hormone and luteinizing hormone. computerized tomography has revealed a pituitary mass without extra-sellar extension. the tumor has completely excised via trans-nasal endoscopic approach. histologically, the tumor has diagnosed as a pituitary adenoma with gh positive cells. the serum igf1 levels have gradually decreased to the normal range and the patient was symptom free for three and a half years when she has returned with complaint of visual impairment. the brain mri that time has shown a supra-sellar mass growing independently into the remaining sellar part. subsequently, surgical operation has performed via trans-nasal endoscopic approach. histopathological and immunohistochemistry examination have revealed a rare case of growth hormone producing pituitary adenoma with brain invasion and lymphocytic infiltration. conclusions: the aim of this publication was to present a rare case of growth hormone producing pituitary adenoma with brain invasion and lymphocytic infiltration.