a common snp of il-10 (-1082a/g) is associated with increased risk of premenopausal breast cancer in south indian women

Background: evading the immune destruction and angiogenesis has been the two hallmarks of cancer. interleukin-10 (il-10) is a cytokine with immune suppressing (pro-tumorigenic) and anti-angiogenic (anti-tumorigenic) properties, thus making the role of il-10 in tumorigenesis enigmatic. previous studies have suggested a critical role of il10 altered expression in complex process of tumor-microenvironment, co-evolution and tumorigenesis.objectives: evaluating the role of il10 (-1082a/g) gene promoter polymorphism in breast cancer patients from south india. patients and methods: a case-control study was conducted with a total of 285 individuals, these include 125 histologically confirmed breast cancer patients and 160 age and sex matched controls. genotypes were determined by allele-specific polymerase chain reaction (as-pcr), followed by agarose gel electrophoresis. statistical analysis was done to test the significance of results obtained. results: statistical analysis revealed that aa genotype of the il-10 -1082a/g polymorphism is significantly associated with breast cancer (aa vs. ag: χ² = 14.46, p = 0.0001432, or = 2.854, 95% ci = 1.68 - 4.849). up on stratifying subjects based on cancer stage, age at onset, menopausal status, aa genotype has associated with all the sub groups, except for post-menopausal women. there was no significant association which was observed with respected to hormonal status (er, pr) and her2/neu status. conclusions: the present study suggests that il-10 aa genotype as a risk factor in the etiology of breast cancer in the south indian population.