outcomes of breast cancer (invasive lobular and ductal carcinoma) treated with boost intraoperative electron radiotherapy versus conventional external beam radiotherapy

Background: breast conserving surgery (bcs) and its following radiotherapy is an accepted therapeutic method for patients with invasive lobular carcinoma (ilc) and invasive ductal carcinoma (idc). objectives: the aim of this study was to investigate the effect of intraoperative electron radiotherapy on women with breast cancer (invasive lobular and ductal carcinoma). methods: between august 2013 and september 2017, 968 patients, who were referred to cancer research center, shahid beheshti university of medical sciences with invasive breast cancer, were treated with breast-conserving surgery and radiotherapy. of those, 426 patients received a tumor bed boost with intraoperative electron radiotherapy (ioert) during lumpectomy (58 patients with pure invasive lobular carcinoma, 239 patients with pure invasive ductal carcinoma, and 129 patients with other diagnoses). 542 patients received a tumor bed boost with conventional external beam radiotherapy post lumpectomy (24 patients with pure invasive lobular carcinoma, 418 patients with pure invasive ductal carcinoma, and 100 patients with other diagnoses). the patients were followed up to 49 months. a comprehensive list of clinical and pathologic features was evaluated for all patients. we retrospectively analyzed outcomes of breast cancer treated with boost intraoperative electron radiotherapy (pure ilc and idc groups) and in other group treated with boost conventional external beam radiotherapy (pure ilc group). results: none of the ilc patients had recurrence in the two groups. the four-year survival rate for ilc patients was 100%, but in the idc group the survival rate was 97%. survival analyses showed patients with idc had a higher risk of ipsilateral breast tumor recurrence (ibtr) and metastasis. conclusions: overall, the rates of ibtr and metastasis in the ilc boost ioert group were significantly low. this finding suggests that ioert technique deployment in ilc had no inferiority compared with the control group.