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ectopic expression of mirna-21 and mirna-205 in non-small cell lung cancer
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نویسنده
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azimi afrooz ,sadegh nia hamid reza ,mosavi jarrahi alireza ,jamaati hamid reza ,kazempour dizaji mehdi ,dargahi hossein ,bahrami naghmeh ,pasdar alireza ,khosravi adnan ,bahrami naeim ,daghighi shadi ,mohamadnia abdolreza
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منبع
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international journal of cancer management - 2019 - دوره : 12 - شماره : 1 - صفحه:1 -6
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چکیده
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Background: lung cancer is the leading cause of death, related to cancer in both men and women. micrornas (mirnas) play key roles in regulating the genes that are responsible for apoptosis, and regulation of gene expression. microrna expression is deregulated in cancer. many efforts have been made to detect cancer biomarkers. extracellular mirnas, which are directly released from tumors, can be detected in circulating blood. objectives: the aim of this study was to examine the expression of mirna-205 and -21 in lung cancer patients relative to healthy controls. methods: this cross sectional study was performed in 50 healthy blood sample controls and 50 non-small cell lung cancer (nsclc) blood samples. the expression of two mirnas (mir-21 and mir-205) in peripheral blood mononuclear cells (pbmcs) was evaluated, using real-time polymerase chain reaction (real-time pcr) techniques. statistical tests were carried out via the mann-whitney test. results: the mir-205 levels of expression in the patients with lung cancer significantly increased in comparison to healthy controls (6.8 ± 0.42 and 1.2 ± 0.19, respectively), (p = 0.014). the expression of mir-21 in lung cancer (5.2 ± 0.52) significantly increased compared to the control group (1.6±0.14) (p < 0.001). conclusions: based on our findings, lung cancer can enhance the ectopic expression of several mirnas, which, in turn, play key roles in impaired apoptosis and further cancerous progression.
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کلیدواژه
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expression ,mir-21 ,mir-205 ,non-small cell lung cancer
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آدرس
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mashhad university of medical sciences, faculty of medicine, department of modern sciences and technologies, ایران, mashhad university of medical sciences, psychiatry and behavioral sciences research center, division of neurocognitive sciences, ایران, shahid beheshti university of medical sciences, medical school, cancer institute research center, department social medicine, ایران, shahid beheshti university of medical sciences, chronic respiratory diseases research center, national research institute of tuberculosis and lung diseases, ایران, shahid beheshti university of medical sciences, masih daneshvari hospital, mycobacteriology research center, national research institute of tuberculosis and lung diseases, biostatistics department, ایران, tehran university of medical sciences, health information management research center, school of public health, management sciences and health economic department, ایران, tehran university of medical sciences, craniomaxillofacial research center, school of dentistry, oral and maxillofacial surgery department, ایران, mashhad university of medical sciences, faculty of medicine, department of modern sciences and technologies, ایران. university of aberdeen, medical school, division of applied medicine, uk, shahid beheshti university of medical sciences, tobacco prevention and control research center, national research institute of tuberculosis and lung diseases, ایران, university of california san diego, department of radiology, usa, university of california san diego, department of radiology, usa, shahid beheshti university of medical sciences, chronic respiratory diseases research center, national research institute of tuberculosis and lung diseases, school of advanced technologies in medicine, department of biotechnology, ایران
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پست الکترونیکی
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mohamadnia.ar@gmail.com
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Authors
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