the effect of fluid therapy in acute post - operative complications of breast cancer; pain and post - operative nausea and vomiting

Background]post operative nausea and vomiting (ponv) still continues to be a serious problem. incidence of ponv is more than 20% to 30%. intravenous fluid administration seems to decrease ponv.[objectives]the aim of this study was to evaluate the effect of pre operative and intraoperative intravenous hydration in comparison to routine hydration on ponv in breast cancer surgery.[methods]this study was performed on 105 female patients with asa class grade i and ii; they were randomly divided to 3; group 1: routine hydration (1.5 cc/kg/h normal saline). group 2: routine hydration + 5 cc/kg of ringer lactate serum 80 to 90 minutes before surgery, and group 3: routine hydration + 5 cc/kg post operative pain, anti emetic and analgesic administration were compared between 3 groups, using vas and cortila questionnaire.[results]there were no significant difference between 3 groups considering demographic data (age, literacy, weight, height, etc.) duration of breast cancer, cancer stage, pre operative fasting time, duration of surgery, etc. blood loss was significantly lower in intraoperative fluid supplementation group (p lt; 0.05), but ponv and post operative pain were significantly lower in those who received pre operative fluid supplementation. they also needed less anti emetic or analgesic administration.[conclusions]pre operative fluid supplementation showed to be an effective prophylactic strategy in ponv. type of fluid and its volume need more evaluation in future studies.