|
|
|
|
the effect of ethanol baneh skin extract on the expressions of bcl - 2, bax, and caspase - 3 concentration in human prostate cancer pc3 cells
|
|
|
|
|
|
|
|
نویسنده
|
amiri maryam ,nasrollahi foad ,barghi siamak ,ebrahimi nazanin ,rajizadeh afsaneh ,dehghan nayyeri nasrin ,kazerouni faranak ,rahimipour ali ,namaki saeed ,ahmadi hadis
|
|
منبع
|
international journal of cancer management - 2018 - دوره : 11 - شماره : 3 - صفحه:1 -5
|
|
چکیده
|
Background: traditional herbs are effective in the treatment of many diseases. it is proven that traditional herbs can decrease the risk of cancer and grow the survivals of patients. objectives: basedonthe results of our previous research, ethanol baneh skin extract has cytotoxic effectonpc3 cells; thus,wedecide to determine the effect of baneh extracts on bcl2 and bax expression and amount of concentration of caspase3. methods: the expressions of apoptotic - related genes were determined by real time pcr and the concentration of caspase3 was determined by elisa method. results: ethanol baneh skin extract increased the mrna expression of bax and decreased the mrna expression of bcl2 in pc3 cells and also increased the amount of caspase3. conclusions: the result of this study indicates the ethanol baneh skin extract including photochemical that might be a candidate for the herbal anti - cancer drugs.
|
|
کلیدواژه
|
expression of bax and bcl - 2 ,concentration of caspase3 ,prostate cancer ,ethanol baneh skin extract
|
|
آدرس
|
jiroft university of medical sciences, school of medicine, department of parasitology, ایران, shahid beheshti university of medical sciences, faculty of medicine, department of immunology, ایران, shahid beheshti university of medical sciences, faculty of paramedical sciences, department of laboratory medicine, ایران, kerman university of medical sciences, medical school, department of biochemistry, ایران, kerman university of medical sciences, health services management research center, institute for futures studies in health, ایران, shahid beheshti university of medical sciences, faculty of paramedical sciences, department of laboratory medicine, ایران, shahid beheshti university of medical sciences, faculty of paramedical sciences, department of laboratory medicine, ایران, shahid beheshti university of medical sciences, faculty of paramedical sciences, department of laboratory medicine, ایران, shahid beheshti university of medical sciences, faculty of medicine, department of immunology, ایران, rafsanjan university of medical sciences, medical school, department of biochemistry, ایران
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|