interpretation of tongue squamous cell carcinoma via protein-protein interaction network construction and analysis

Background: tongue squamous cell carcinoma is one of the prominent cancers in the oral cavity. molecular investigations based on interaction analysis can be promising towards providing a better resolution of malignant neoplasms. here, the protein-protein interaction network of tongue cancer is studied. methods: the protein-protein interaction network was constructed by the application of cytoscape 3.5.1 and the related algorithms. centrality analysis via the degree, betweenness, and closeness centralities was conducted. results: the result indicated that there are seven chief proteins in the network foundation. moreover, enrichment evaluation suggested two associated biological processes including response to uv-a, response to interlukin-7, cellular response to alcohol, and catenin import into nucleus process using cluepedia. conclusions: it can be concluded that the identified central panel proteins and their related biological processes can shed light on the neoplasm mechanisms and are worth pursuing for clinical approaches.