predictive factors of steatosis and non-alcoholic steatohepatitis in morbidly obese patients undergoing bariatric surgery

Background and objectives: obesity is one of the most health-threatening phenomena. it is estimated that over 1 billion adults have overweight or obesity. the current study aimed at presenting a detailed account of the findings that attempted to predict the severity of fatty liver disease and its sequelae, including non-alcoholic steatohepatitis (nash), fibrosis, and cirrhosis, by correlating biopsy results with liver function tests and various metabolic markers of laboratory results in patients with morbid obesity. methods: a total of 111 subjects participated in the study. the collected data included pathology study of liver biopsy, fasting blood glucose (fbs), liver function test (lft), and lipid profile. results: the correlation between fibrosis and steatosis was 0.493 (p = 0.001, 95% confidence interval (ci) and correlation between fibrosis and nash grade was 0.531 (p = 0.001, 95%ci). there was a significant relationship between aspartate aminotransferase (ast) and triglyceride (tg) with steatosis intensity and a significant positive relationship between ast, cholesterol, and fbs with nash intensity. conclusions: levels of serum ast andtg showed significant relationship with steatosis and fibrosis intensities; ast, fbs, and cholesterol had a significant correlation with nash intensity. cholesterol and low-density lipoprotein (ldl) levels had an inverse monotonic relationship with fibrosis intensity.