how does addition of regular aerobic exercises, influence the efficacy of calorie-restricted diet in patients with non-alcoholic steatohepatatis (nash)?

Background nonalcoholic fatty liver (nafld) is a worldwide, leading cause of chronic liver disease, not yet approved medical treatment standards. the aim is to assess the effects of aerobic exercise sand calorierestricted (cr) diet on many clinical and laboratory findings in patients with nonalcoholic steatohepatatis (nash). methods in randomized controlled trial study, in mashhad, between february 2010 august 2011, twentyfive patients with nash, in ranging ages of 18 55, were randomly selected to be divided in to two groups, who received crdiet and aerobic exercise (n = 12) and crdiet alone (n = 13). we measured anthropometric indices, cardiorespiratory fitness, and biochemical profiles in three steps, in baseline, and after 8 12 weeks of intervention. we measured hepatic steatosis and patient’s quality of life by ultrasonography and short form (questionnaire) 36 in three steps. data was then analyzed by paired and independent samples t test. results we observed a significant improvement in bp, fbs, tg, homair, ultrasonography grading of steatosis and quality of life, only in patients who received aerobic exercises. (p value 0.021, 0.005, 0.006, 0.042, 0.010 and 0.012). waist circumference, waisttoheight ratio, serum alt and peak oxygen consumption improved in both groups; however, improvement was significantly, higher in patients who received aerobic exercises (p value 0.027, 0.011, 0.020 and 0.020). body weight, bmi, body fat percentage and ast improved in both groups but they were not significantly different. no significant changes noted in total cholesterol, ldl and hdl in groups. conclusions add of aerobic exercises to cr diets can, not only enhance the therapeutic effects of calorierestricted diet, but also bring more benefits in patients with nash.