association of liver enzymes with 10-year cardiovascular disease risk: a population-based study

Background: the association between liver enzymes and cardiovascular disease (cvd) was previously demonstrated. this studyinvestigated the possible association between liver enzymes and the 10-year risk of cardiovascular events.methods: the study consisted of 3199 subjects. tworisk-assessment methods, the framinghamrisk score (frs) and american collegeof cardiology and american heart association (acc/aha) tools, were used to predict 10-year cardiovascular risks. the associationbetween liver enzymes and≥ 7.5%,≥ 10%, and≥ 20% 10-year cvd risks were evaluated.results: in the multivariate analysis, alkaline phosphatase (alp) was significantly associated with 10-year cvd risks in both menand women (p < 0.05). no significant association was detected between 10-year cvd risks and gamma glutamyl transferase (ggt).according to both risk-assessment tools, alanine aminotransferase (alt) showed a significant inverse association with 10-year cvdrisks in men (all p < 0.001). in contrast, this association was significant in women only for≥ 7.5% and≥ 10% 10-year risks using theacc/aha (p = 0.018) and framingham tools, respectively (p = 0.028).conclusions: while alp exhibited an independent positive association with 10-year cvd risks in both genders, alt showed an inverseassociation with10-year cvd risks in men and with some levels of risks in women.