Editorial: Acute Fatty Liver of Pregnancy: A Life-Threatening Condition Requiring a Life-Saving Approach

Dear editor, the accumulation of fatty acids in the hepatocytes, which is caused by different pathophysiologic mechanisms, is known as fatty liver disease. for instance, metabolic syndrome or obesity, in which lipolysis is suppressed as a result of hyperinsulinemia, would consequently provoke non-alcoholic fatty liver disease (nafld) or themoresevere non-alcoholic steatohepatitis (nash). in the long-term, this condition could result in liver cirrhosis. however, when it occurs during the gestational period, it is termed acute fatty liver of pregnancy (aflp). rather than an indolent chronic disease, aflp is a devastating condition that can rapidly progress to fulminant hepatic failure with associated coagulopathy or hepatic encephalopathy. in this scenario, the lives of two individuals (i.e., mother and infant) are inevitably jeopardized.