Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population

Background: il-10 can play a vital role in immune response against hbv. three biallelic snps from the transcription start site control the transcription of the il-10 gene. an association between susceptibility to hbv and il-10 polymorphisms has been suggested in patients with hbv infection. objectives: the present study was designed to study the association between polymorphisms in interleukin-10 (-1082 a/g, -819 t/c and -592 a/c) promoter gene and chronic hepatitis b virus (hbv) infection. patients and methods: 221 chronically infected patients and 200 healthy control subjects were enrolled in the study. three biallelic (-1082 a/g, -819 t/c and -592 a/c) polymorphisms in the il-10 promoter gene were determined by pcr-rflp method. results: persistent hbv infection was associated with il-10-1082 ag (p = 0.001) and gg (p = 0.004) genotypes and g (p = 0.000) allele. il-10-819 t/c and -592 a/c genotype and allele frequencies did not show any correlation with the risk of chronic hepatitis b infection. conclusions: these results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of hbv infection and susceptibility to hbv infection.