Autoantibodies in Hepatitis CVirus-Related Chronic Liver Disease

Persistent hepatitis e virus (hey) infection evokes autoimmune response including production of autoantibodies andconcomitant autoimmune disorders. numerous types of autoantibodies such as non-organ-specific autoantibodies andliver-specific autoantibodies have been identified in sera of patients with hey-related chronic liver disease (eld). theproduction of these autoantibodies in hey-related eld reflects virus-induced autoimmunity. molecular mimicrybetween the hey polyprotein and self-proteins, and polyclonal b cell activation by chronic hey infection have beenproposed as possible mechanisms for the occurrence of autoantibodies in hey-related eld. some autoantibodies aretightly associated with concurrent autoimmune diseases, and others closely associated with peculiar human leukocyteantigen (hla) haplotypes. changes in the titers of autoantibodies during the antiviral treatment may predict thesustained virological response in individuals. in this article, we mainly focus on the interpretations of autoantibodies inhey-related eld.