Serological Markers of Blood Borne Viruses among Persons with Combined Factor V &VIII Deficiency

Background and aims: combined factor v and viii deficiency (cf5f8d) is a rare hemorrhagic disorder. treatment ofpatients with blood products has been associated with infections with blood-borne viruses. due to absence of anysurvey on status of blood borne viruses in individuals with cf5f8d, we tried to address this question.methods: among 25 known cases, 24 individuals were assessed for hepatitis band c viruses (hbv &. hcv), human tiymphotropic virus type one (htlv-i) and human immunodeficiency virus type1/2 (hiv1/2) using enzyme linkedimmunosorbent assay method.results: in the group under survey, 2 cases (8.3%) were positive for anti-hcv. there was no infection with hbv, htlviand hiv.conclusions: hepatitis c is a major health problem in cf5f8d, as in hemophiliacs, and may need more attention frommanufacturers of blood products and more careful pre-transfusion screening of blood products for anti-hcv.