Seroepidemiology of Hepatitis C in Kermanshah (West of Iran, 2006)

Background and aims: chronic and serious outcomes of hepatitis c virus (hcv) infection impose a remarkable economicburden to the health system. the aim of this study was to evaluate the prevalence of hcv infection in the generalpopulation of kermanshah in the year 2006.methods: in this cross-sectional study, 1721 residents from kermanshah were chosen by systematic and clustersampling in the year 2006. after interview, serum samples were taken and evaluated for hcv-ab using elisa method(3'· generation). positive samples were confirmed by western blot (wb) and pcr if necessary.results: the prevalence of hcv was 0.87% (male: 1.4% vs. female: 0.3%). there was 88.2% coordination betweenelisa and wb results. statistical relationship was observed between hcv infection and male sex (p(less than)0.018), history ofaddiction (p(less than)o.oool), shared needle (p(less than)o.oool), unsafe sexual contact (p(less than)0.008), history of blood and blood productstransfusion (p(less than)o.oool), tattooing (p(less than)o.oool), history of incarceration (p(less than)o.oool), and hemophilia (p(less than)o.oool). on theother hand, stepwise logistic regression analysis showed that hemophilia, shared needle, iv addiction, transfusion andaddiction were the most important risk factors for hcv infection in a descending order. the rate of hcv infectionincreased in cases with multiple risk factors.conclusions: we estimate that among 967196 people, who live in kermanshah, nearly 8400 individuals may have hcvinfection and this will be a major problem in the near future. addicts especially iv drug users and cases with the historyof blood and blood products transfusion are high risk groups who need special attention regarding hcv infection.