Risk Factors, Complications and Prognosis of Cirrhosis in a Tertiary Care Hospital of Peshawar

Background and aims: to determine the risk factors, complications and prognosis of cirrhosis in a hospital based studyat peshawar.methods: a descriptive cross sectional study, in medical department, khyber teaching hospital peshawar, from april2005 to march 2006.relevant informations were recorded from patients and treatment chart of the patients, on aquestionnaire designed in accordance with the objectives of the study.results: a total of 61 patients, 41(67.21%) males and 20(32.78%) females were included. the age range of thepatients was from 36 to 75 years with mean age of 57.5 years. forty-four patients (72.33%) had family history ofchronic liver diseases. the risk factors distribution was: chronic hepatitis b infection (13.11%), chronic hepatitis cinfection (59.01%), chronic hepatitis b and c co-infection (8.19%), biliary cirrhosis (3.27%), wilson disease(1.63%) and no risk factors recorded were recorded in (14.75%) patients. complications of liver cirrhosis recordedwere: ascites (27.86%), variceal hemorrhage (18.03%), hepatorenal syndrome (3.27%), encephalopathies (1.63%),hepatocellular carcinoma (1.63%) and no complications were recorded in (47.54%) patients. prognosis of patientswith cirrhosis based on modified child's pugh classification was studied in only 30(49.18%) of patients. out of thirtypatients 25(83.33%) had child's 'a' grade of prognosis, 4(13.33%) child's 'b' grade and 1(3.33%) child's 'c' grade.conclusions: chronic hepatitis band c infections were the major risk factors for cirrhosis. ascites and variceal bleedingwere recorded as major complications of cirrhosis and majority of our patients fit in child's a grade of prognosis with45% chances of 5 years survival.