Comparative Analysis of Risk Factors and Complications of Hepatitis Band C Infections at Khyber Teaching Hospital, Peshawar

To analyze comparatively the risk factors and complications of hepatitis band c infections atkhyber teaching hospital, peshawar.methods: a cross-sectional observational study was conducted in department of medicine, khyber teaching hospital,peshawar, from march 2005 to october 2006. relevant information's were obtained from the patients with the aid of apre-designed questionnaire prepared in accordance with the objectives of the study.results: a total of 432 patients with positive anti-hcv antibody 252 (58.33%) and positive hbs ag 180 (41.66%) wereincluded. the age range of the patients with anti-hcv antibody was from 11 to 84 years with the mean age of 47.5years, while in hbv cases was 50.5 years (range: 7 to 87 years). in hcv positive cases, 165 (65.47%) were males and87 (34.52%) were females while in hbv patients, 123 (68.33%) were males and 57 (31.67%) were females. the riskfactors of hcv patients were: intravenous drug users, 23.81%; hcv positive sexual partners, 15.07%; blood or bloodproducts transfusion, 13.49%; and occupational acquired-hcv, 7.14%. the major risk factors of hbv were: intravenousdrug users, 33.88%; hbsag positive sexual partners, 23.33%; blood transfusion, 14.44%; and dental procedures (toothextraction or root canal treatment), 9.44%. unknown source of infection was recorded in 25% of hcv and 10.56% ofhbv patients. complications consequences in hcv patients were: chronic hepatitis, 34.52%; liver cirrhosis, 16.26%;hepatocellular carcinoma, 0.79%; fulminant hepatitis, 0.79%; while 47.61% were asymptomatic or sub-clinicalsymptomatic. in hbv patients, complications were acute hepatitis, 5.56%; fulminant hepatitis, 0.5%; chronic healthycarriers, 31.67%; chronic hepatitis, 24.44%; liver cirrhosis, 6.11%; and hepatocellular carcinoma, 1.10%; while40.55% were clinically asymptomatic or with sub-clinical disease. coexistence of hcv and hbv were recorded in 52(12.03%) patients.conclusions: history of sexual transmission favors hbv infection while blood transfusion and occupational exposurewere recorded mainly in hcv positive patients. chronic persistent hepatitis and liver cirrhosis were recorded moresignificantly with hcv infection while hbv favor carrier state or presents as a sub-clinical disease.