Lack of Association Between Transforming Growth Factor Beta 1 -509C/T and +915G/C Polymorphisms and Chronic Hepatitis B in Iranian Patients

Background: chronic hepatitis b is one of the world's major health concern. the etiological agent of this infection is hepatitis b virus (hbv), which can evade the immune system response. transforming growth factor beta 1 (tgf-β1) can act against hbv by suppressing the viral replication. the tgf-β1 also plays an important role in preventing liver damage in chronically hbv infected patients.objectives: in this study, the association of tgf-β1 +915g/c and -509c/t gene polymorphisms with chronic hepatitis b was evaluated in iranian patients. materials and methods: a population-based case–control study was conducted in taleghani hospital, tehran. a number of 220 patients with chronic hepatitis b and the same number of healthy control subjects were designated the case and the control groups. the pcr-restriction fragment length polymorphism method (pcr-rflp) method was used for genotyping both polymorphisms. ten percent of the control samples were sequenced to confirm the results. results: no statically significant differences in genotype distribution and allele frequency were observed for both polymorphisms between healthy controls and patients with chronic hepatitis b. conclusions: there was no association between tgf-β1 -509c/t and +915g/c polymorphisms with chronic hepatitis b and it seems that these changes don not play a significant role in increasing the risk of chronic infection in iranian patients.