Skin Adverse Events During Dual and Triple Therapy for HCV-Related Cirrhosis

Introduction: dermatological adverse events are an existing concern during treatment of hepatitis c virus infection. peginterferon/ribavirin treatment is associated with well-characterized dermatological lesions tending towards a uniform entity of dermatitis. new telaprevir- or boceprevir-based triple-therapy has led to significant improvements in sustained virological response rates, although associated with an increase in cutaneous adverse events compared peginterferon/ribavirin alone.case presentation: we report a case of a patient who discontinued telaprevir because of severe skin eruptions and who, during ribavirin and interferon treatment, after a period free of skin lesions, developed new dermatological lesions different than those experienced during telaprevir treatment.conclusions: several adverse effects are associated to anti-hcv drugs, hence appropriate skin care management and follow-up are very important. a careful anamnesis before the initiation of triple therapy is necessary to identify previous dermatological diseases that could increase skin adverse effects incidence.