The 24 Hour Urine Creatinine Clearance for Prediction of Glomerular Filtration Rate in Liver Cirrhosis Patients: Have We Considered All Elements?

The correct estimation of renal function in patients with liver cirrhosis and chronic kidney disease (ckd) is difficult (1, 2). direct measurement of glomerular filtration rate (gfr) using exogenous markers (iohexol or iothalamate) is considered the reference to assess renal function in cirrhotic patients ( 1 , 2). however, direct measurement of gfr is not available at all transplant centers. the 24 hour urine creatinine clearance (crcl) is widely used to measure gfr, and is calculated by multiplying the ratio of urine creatinine (cr) to plasma cr by 24 hours urine volume.