Tripartite Motif-Containing 22 Gene -364T/C Polymorphism Associated With Hepatitis B Virus Infection in Chinese Han Population

Background: hepatitis b virus (hbv) infection significantly contributes to the onset of liver disease and hepatocellular carcinoma. understanding the pathogenesis of hbv infection susceptibility could help us to control hbv infection effectively. objectives: this study investigated single nucleotide polymorphisms (snps) of the tripartite motif-containing 22 (trim22) gene associated with hbv infection outcome. patients and methods: a total of 765 chinese han subjects were enrolled: 293 patients were presented with chronic hepatitis b (chb), 224 were asymptomatic hbv carriers, 248 had self-limited hbv infection, and all of them were recruited for trim22 snps genotyping. ring and spry domains of trim22 gene were dna-sequenced, and hbv serum markers and hbv dna were measured quantitatively in all subjects. results: 243 (31.76%) of 765 chinese han patients showed genetic variation in the trim22 gene. trim22 snps were mainly in ring area -364t/c site, accounting for 98.35% of the population. there were no significant differences (p > 0.05) in the ring domain -364t/c snp and allele frequencies between patients with chronic hepatitis and asymptomatic hbv carriers. the cc genotype of trim22 gene ring domain -364t/c locus (rs10838543) was associated with chronic hbv infection (or = 2.30, 95% ci = 1.24-3.97, p = 0.0012; or = 2.26, 95% ci = 1.08-3.74, p = 0.002) and a mutant allele c carrier of the trim22 gene was associated with hbv chronic infection (or = 1.97, 95% ci = 1.10-3.75, p = 0.0049; or = 2.12, 95% ci = 1.17-3.89, p = 0.0038). conclusions: trim22 gene ring domain -364t/c polymorphism is associated with chronic hbv infection in chinese han population.