No Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome

Background: single nucleotide polymorphisms (snp) in the promoter region of the interleukin (il)-10 genes have a role in determining hepatitis b virus (hbv) outcome. objectives: this study evaluates the correlation between hbv infection and snp in il-10 gene promoter. patients and methods: ninety-six hbv-infected patients (32 chronic hepatitis b infection patients, 34 healthy carriers, 30 spontaneously recovered cases) and 31 healthy controls were enrolled. three biallelic (-819,-592,-1082) regions in the il-10 gene promoter were sequenced for all patients. results: genotypes and haplotypes of il-10 gene promoter region at position -1082, -819 and -592 were not significantly different among controls, hbv recovered cases, carriers and chronic hbv patients. nevertheless, a/a genotype at position -592 and t/t genotype at position -819 were more frequently seen in the hbv clearance group, while frequency of g/g genotype at position -1082 was more prevalent in the persistence group. gcc/gcc and gcc/acc haplotypes were significantly observed in anti-hbe positive individuals. conclusions: our findings showed that il-10 promoter polymorphisms were not correlated with hbv infection prognosis. nevertheless, individuals carrying high and intermediate producer of il-10 haplotypes had a better ability to develop anti-hbe than low producer carriers.