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non-invasive assessment of liver damage degree in patients with viral hepatitis: is it feasible and acceptable?
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نویسنده
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vračarić vladimir ,dejanović božidar ,janjić nebojsa ,zirojević milica ,savić željka ,bosnjak olgica latinović ,orlić tihomir ,krnetić žarko ,damjanov dimitrije ,pete maria ,ružić maja
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منبع
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hepatitis monthly - 2024 - دوره : 24 - شماره : 1 - صفحه:1 -8
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چکیده
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Background: hepatitis c and b virus infections significantly contribute to global chronic liver disease mortality.objectives: this study explores the role of serum markers (ast/alt ratio, apri score, fib-4 score, and forns index) in non-invasively assessing liver damage in patients with chronic hepatitis c and b. methods: in this single-center, retrospective, observational study, we analyzed data from 327 patients to establish correlations between serological markers and fibrosis grade using spearman's correlation. receiver operator characteristic (roc) analysis evaluated the ability of these markers to predict advanced fibrosis. results: in hepatitis b and c cohorts, all markers show significant positive correlations with liver fibrosis (p < 0.001). fib-4 and the forns index exhibit moderate correlation (spearman’s rho 0.48), while ast/alt and apri score show mild correlation (spearman’s rho 0.21 and 0.31). in hepatitis c, the forns index (0.814) and fib-4 (0.80) outperform other markers. in hepatitis b, forns (auc = 0.73), apri (auc = 0.68), and fib-4 (auc = 0.68) demonstrate significant predictive ability. conclusions: fib-4 and the forns index hold clinical significance as fibrosis biomarkers in the management of chronic viral hepatitis. fib-4 is a universal marker, while the interpretation of the forns index requires consideration of the etiology of chronic viral hepatitis.
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کلیدواژه
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hepatitis b ,hepatitis c ,liver fibrosis ,cirrhosis ,apri ,fib-4 ,forns
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آدرس
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university of novi sad, faculty of medicine, serbia. university clinical center of vojvodina, clinic of gastroenterology and hepatology, serbia, university of novi sad, faculty of medicine, serbia. university clinical center of vojvodina, clinic of gastroenterology and hepatology, serbia, university of novi sad, faculty of medicine, serbia. university clinical center of vojvodina, clinic of gastroenterology and hepatology, serbia, university of novi sad, faculty of medicine, serbia. university clinical center of vojvodina, clinic for endocrinology, diabetes and metabolic disorders, serbia, university clinical center of vojvodina, clinic of gastroenterology and hepatology, serbia. university of novi sad, faculty of medicine, serbia, university of novi sad, faculty of medicine, serbia. university clinical center of vojvodina, clinic of gastroenterology and hepatology, serbia, university clinical center of vojvodina, clinic of gastroenterology and hepatology, serbia, university of novi sad, faculty of medicine, serbia. university clinical center of vojvodina, clinic of gastroenterology and hepatology, serbia, university clinical center of vojvodina, clinic of gastroenterology and hepatology, serbia. university of novi sad, faculty of medicine, serbia, university of novi sad, faculty of medicine, serbia. university clinical center of vojvodina, clinic for infectious disease, serbia, university of novi sad, faculty of medicine, serbia. university clinical center of vojvodina, clinic for infectious disease, serbia
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پست الکترونیکی
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maja.ruzic@mf.uns.ac.rs
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Authors
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