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oral zinc supplementation in chronically hev-infected patients not responding to ribavirin monotherapy
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نویسنده
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horvatits thomas ,behrendt patrick ,schuebel niels ,guthoff martina ,wiegand johannes ,harth anna ,mersi julia ,luetgehetmann marc ,gallon clemence ,rybczynski meike ,liang zhaochao ,maasoumy benjamin ,mallet vincent ,wang lin ,pischke sven
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منبع
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hepatitis monthly - 2023 - دوره : 23 - شماره : 1 - صفحه:1 -7
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چکیده
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Background: chronic hepatitis e virus (hev) infection may progress to end-stage liver disease in immunosuppressed individuals. ribavirin therapy is efficient in most chronic hev patients, but 10% remain without a sustained virological response (svr). objectives: we aimed to study whether zinc supplementation could represent a therapeutic approach in these patients. methods: antiviral properties of zinc salts were studied in vitro (subgenomic-replicon system), in vivo (rabbit model), and retrospectively in patients with chronic hepatitis e who did not achieve svr under ribavirin monotherapy. results: zinc inhibited hev genotype 3 replication in vitro. in a model of acute hev infection in immunocompetent rabbits, zinc + ribavirin did not improve viral clearance compared to ribavirin monotherapy. in chronically hev-infected patients not responding to ribavirin (n = 12), viral clearance was observed in 4/12 (33%) patients receiving additional zinc supplementation. conclusions: oral zinc, an inexpensive, harmless dietary supplement, could potentially represent a rescue treatment option for a few patients with chronic hepatitis e without svr under ribavirin monotherapy. further studies are needed to elucidate the role of zinc in hev.
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کلیدواژه
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hepatitis e ,hev ,antiviral ,zinc
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آدرس
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university medical center hamburg-eppendorf, department of medicine i, germany, hanover medical school, department of gastroenterology, hepatology and endocrinology, germany, infectious diseases center, klinikum osnabrück, germany, university of tuebingen, department of diabetology, endocrinology, nephrology, section of nephrology and hypertension, germany, leipzig university, medical center, department of medicine ii, division of hepatology, germany, medical center cologne-merheim, germany, university hospital wurzburg, department of oncology, germany, university medical center hamburg-eppendorf, institute of microbiology, virology and hygiene, germany, university of paris, public assistance-hospitals of paris, cochin hospital-port royal, hepatology service, france, university medical center hamburg-eppendorf, university heart center, germany, peking university, infectious disease center, health science center, school of basic medical sciences, department of microbiology, china, hanover medical school, department of gastroenterology, hepatology and endocrinology, germany, university of paris, public assistance-hospitals of paris, cochin hospital-port royal, hepatology service, france, peking university, infectious disease center, health science center, school of basic medical sciences, department of microbiology, china, university medical center hamburg-eppendorf, department of medicine i, germany
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پست الکترونیکی
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s.pischke@uke.de
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Authors
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