relationship between 25-hydroxyvitamin d level and liver stiffness in patients with chronic hepatitis b using transient elastography

Background: studies are limited on the relationship between vitamin d levels and liver fibrosis in patients with hepatitis b. objectives: a study was conducted to investigate the relationship between 25-hydroxyvitamindlevels and liver stiffness in patients with hepatitis b. methods: in a cross-sectional study, serum 25-hydroxyvitamin d levels and liver stiffness, measured by transient elastography (te), were evaluated in 281 patients with hepatitis b. the predictors of liver stiffness and its relationship with 25-hydroxyvitamin d level, coinfection with hepatitis d, age, and viral load were determined using multivariate analysis. results: a significant correlation was observed between 25-hydroxyvitamin d deficiency and liver stiffness. based on multivariate analysis, factors that were independently associated with advanced liver fibrosis included vitamin d level (p < 0.001), coinfection with hepatitis d (p < 0.001), and age (p < 0.001). among 281 patients, the frequency of vitamin d deficiency (< 10 ng/ml), insufficiency (≥ 10 and < 20 ng/ml), and adequacy (≥ 30 ng/ml) was 40 (14.2%), 150 (53.4%), and 91 (32.4%), respectively. conclusions: in hepatitis b patients, vitamin d deficiency was independently associated with advanced liver fibrosis. an increase in age and coinfection with hepatitis d were also directly related to liver stiffness.