king’s fibrosis, fibrosis index, gpr, and albi score are useful models for liver fibrosis in chronic hepatitis b patients pre- and post-treatment

Background: liver fibrosis is one of the chronic hepatitis b (chb) indications for treatment. objectives: we aimed to assess the fibrosis index, fib-4, king’s fibrosis score, albumin-bilirubin (albi) score, gamma-glutamyl transferase-platelets (gpr), and gamma-glutamyl transferase-albumin (gar) ratios as diagnostic models of liver fibrosis in chb patients. methods: the study enrolled 217 patients. liver fibrosis was assessed by transient elastography, which showed 20.3% of the patients had f4 fibrosis. treatment was given for 33.20±20.94 months. results: f4 fibrosis patients had higher values (p = 0.001) of fibrosis index score, fib-4 score, king’s fibrosis score, albi score, gpr, andgarthan non-f4 fibrosis patients. all patients had improved values after treatment. themeantreatment-induced changes were comparable in patients with and without virological response. the fibrosis index of > -32.66 showed 63.64% sensitivity and 91.33% specificity. the fib-4 score of > 1.88 had 72.73% sensitivity and 91.33% specificity. the king’s fibrosis score of > 7.93 demonstrated 90.91% sensitivity and 73.99% specificity. the albi score of > -2.7 had 70.45% sensitivity and 86.13% specificity. the gpr value of > 0.69 revealed 70.5% sensitivity and 94.2% specificity. the gar value of > 1.28 showed 72.73% sensitivity and 46.4% specificity. the gar was inferior to fib-4 and gpr (p < 0.05). conclusions: gpr, fibrosis index, king’s fibrosis score, albi, and fib-4 are useful diagnostic models of liver fibrosis in chb patients.