Hepatitis C Virus Cryoglobulinemia and non-Hodgkin Lymphoma

Context: on the strength of epidemiological data,biological studies, and clinical findings, hepatitis c virus appears to be involved in the pathogenesis of a proportion of patients with non-hodgkin lymphoma and cryoglobulinemia.objectives: the aim of this paper is to review the published literature focused on the current knowledge concerning hepatitis c virus and its potential role in the production of non-hodgkin lymphoma and cryoglobulinemia in susceptible individuals.evidence acquisition: in this review, databases such as pubmed, embase, isi, and iranian databases including iranmedex, and sid were searched.results: the results of this review indicate that hcv infection may be a likely cause of various b cell dysregulation disorders such as non-hodgkin lymphoma and cryoglobulinemia.conclusion: based on current findings, it has been hypothesized that nhl and cryoglobulinemia in hcv infection may have an immune-mediated pathogenesis. in hcv infected patients, we showed an elevated risk of these two diseases. these finding suggested a possible role for chronic hepatitis c in the pathogenesis of nhl and cryoglobulinemia.