The Correlation of Il28B Genotype With Sustained Virologic Response in Romanian patients With Chronic Hepatitis C

Background: multiple variables influencing the sustained virologic response (svr) in chronic hepatitis c have been evaluated. one of them is genetic polymorphism near the il28b gene.objectives: the aim of this study was to evaluate the influence of il28b genotypes on svr rates in a group of patients with chronic hepatitis c from the western part of romania.patients and methods: a retrospective study was performed in 107 consecutive patients, previously treated with standard-of-care medication for chronic hepatitis c, identified from the databases of 2 centers. patient demographics, viral load before treatment and at 12, 24, and 72 weeks from the treatment start, and il28b genotype were evaluated.results: among the 107 patents in the study group, 54 patients had svr (50.5%), and 62 (57.9%) showed a complete early virologic response (cevr). the svr rates according to il28b genotype were as follows: 73.1% in patients with genotype c/c, 40.9% in those with genotype c/t, and 57.1% in those with genotype t/t (i.e., 73.1% among patients with the c/c genotype vs. 43.7% among those with non-c/c genotypes; p = 0.0126). the cevr rates were 80.8% in patients with the c/c genotype vs. 51.2% in those with non-c/c genotypes (p = 0.011).conclusions: in our cohort of 107 caucasian hcv patients, the svr rate was 50.5% with standard-of-care treatment. the svr rate was directly related to the il28b genotype: 73.1% in the c/c genotype vs. 43.7% in non-c/c genotypes (p = 0.0126).