Hepatitis B Vaccination Reliability in Celiac Disease

Vaccination is an efficient and reliable means of protection against common hepatitis b virus (hbv) infections (1). between 90% and 95% of the adult population responds to hbv vaccination (2, 3), and 4–10 % of vaccine ecipients fail to respond to standard immunization (1, 4, 5). the ability to respond to recombinant hbv vaccine is associated with immunogenetically condition because of multiple candidate genes (6, 7). some specific hla haplotypes are considered to be the most important genetic markers for non-responders, who are found to carry specific haplotypes such as b8, dr3, and dq2 (6, 7). since hla genotypes play an important role in unresponsiveness to the hbv vaccine, celiac disease (cd) may be associated with this unresponsiveness (8). cd is a common autoimmune disorder, which has a particularly strong association with the presence of hla-dq2 in 90–95% of the patients (9-12).