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Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population
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نویسنده
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Wu Liming ,Chen Lin ,Zhou Lin ,Xie Haiyang ,Wei Bajin ,Yin Shengyong ,Ye Yufu ,Fang Weijia ,Zheng Shusen
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منبع
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hepatitis monthly - 2011 - دوره : 11 - شماره : 6 - صفحه:469 -474
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چکیده
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Background: there is growing evidence suggesting that interleukin-18 (il-18) plays a crucial role in viral clearance and disease pathogenesis, and that single nucleotide polymorphisms (snps) within the gene may influence its production.objectives: to investigate the potential association of two polymorphisms ( 137g/c and 607c/a) in the promoter region of the il-18 gene with the risk of hbv recurrence after liver transplantation (lt) in han chinese patients.patients and methods: il-18 promoter genotyping was performed by the snapshot technique in 125 patients with hbv-related end-stage liver disease (esld) receiving lt in our center from 2004 to 2008.results: among the study samples, no significant association between the il-18 promoter polymorphisms ( 137g/c and 607c/a) or haplotypes and hbv recurrence after lt was found.conclusions: the polymorphisms ( 137g/c and 607c/a) in the promoter region of the il-18 gene may not play a key role in hbv recurrence after lt in han chinese population, and may not be suitable predictors for hbv recurrence in clinical practice.
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کلیدواژه
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Interleukin-18; Genetic polymorphism; Hepatitis; Recurrence; Transplantation
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آدرس
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Ministry of Public Health, Key Laboratory of Combined Multi-Organ Transplantation, China. Zhejiang University, School of Medicine, Department of Hepatobiliary and Pancreatic Surgery, China, Zhejiang University, School of Medicine, China, Ministry of Public Health, Key Laboratory of Combined Multi-Organ Transplantation, China. Zhejiang University, School of Medicine, Department of Hepatobiliary and Pancreatic Surgery, China, Ministry of Public Health, Key Laboratory of Combined Multi-Organ Transplantation, China. Zhejiang University, School of Medicine, Department of Hepatobiliary and Pancreatic Surgery, China, Zhejiang University, School of Medicine, China, Ministry of Public Health, Key Laboratory of Combined Multi-Organ Transplantation, China. Zhejiang University, School of Medicine, Department of Hepatobiliary and Pancreatic Surgery, China, Zhejiang University, School of Medicine, China, Zhejiang University, School of Medicine, Department of Medical Oncology, China, Ministry of Public Health, Key Laboratory of Combined Multi-Organ Transplantation, China. Zhejiang University, School of Medicine, Department of Hepatobiliary and Pancreatic Surgery, China
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پست الکترونیکی
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shusenzheng@zju.edu.cn
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Authors
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