effects of green coffee bean extract supplementation on patients with non-alcoholic fatty liver disease: a randomized clinical trial

Background: non-alcoholic fatty liver disease (nafld) is a major worldwide public health problem with no effective treatment options. green coffee bean extract (gcbe) is a rich source of bioactive phytochemicals with a variety of biochemical and physiological effects. objectives: the aim of this study was to investigate the effects of gcbe on the management of patients with nafld. methods: 44 patients with nafld were enrolled in a parallel, double-blind, placebo-controlled clinical trial. the participants were administered either gcbe or placebo (1 gram/day) for 8 weeks. they also were advised to follow a standard energy-balanced diet and physical activity. liver ultrasonography, anthropometric variables, and biochemical parameters were compared at pre- and post-intervention. results: gcbe significantly improved the levels of aspartate aminotransferase (ast), triglyceride (tg), total cholesterol, free fatty acids (ffas), fasting blood sugar (fbs), homeostasismodelassessment insulin resistance (homa-ir) index, high-sensitivity c-reactive protein (hs-crp), and total antioxidant capacity (tac) compared to the placebo group. on the other hand, there were no significant differences between the two groups in body weight, hdl-cholesterol, ldl-cholesterol, ldl-c tohdl-c ratio, insulin, degree of steatosis, aspartate transaminase (ast), alkaline phosphatase (alp), and tumor necrosis factor-alpha (tnf- ). conclusions: gcbe supplementation may benefit patients with nafld. these beneficial effects may be due to the possible ability of gcbe to improve insulin sensitivity and its anti-inflammatory and antioxidant properties.