Relationship Between Bmi and Depression, According To the Rs16139npy Gene

Objective: obesity and depression are likely to interact mutually, which makes it unclear whether obesity causes depression or depression leads to obesity, and how the genotypes have a role in obesity and depression. method: this cross- sectional study was conducted on a sample of 400 individuals from the participants in the third phase of the comprehensive iranian multicenter osteoporosis study (imos). anthropometric measurements and depression were assessed. pcr-rflp was used to investigate the npy polymorphism. binary logistic regression model was employed to determine depression as the dependent factor and gene polymorphism. results: the frequency of npy rs16139 was 6%. no significant association was found between npy genotypes and depression (p >0.05). furthermore, the results suggest that those with central obesity had an increased chance of developing depression (p = 0.02) . conclusion: the frequency of npy polymorphism was 6%. our study could not find a correlation between rs16139 and depression.