serum vitamin d, mania and depression-related scores: a comparison among mixed bipolar, mania, and healthy subjects

Objective: manic and mixed episodes of bipolar disorder are important episodes of this disorder. the aim of the current study was to assess serum vitamin d (svd) levels in patients with mania and mixed bipolar disorder, compared to healthy subjects.method: the current cross-sectional study was conducted on 75 subjects, including healthy subjects (n = 25), patients with acute-phase mania (n = 25), and patients with mixed bipolar disorder (n = 25). the svd levels were measured in all of the enrolled subjects. the hamilton depression rating scale (hdrs), young mania rating scale (ymrs), and clinical global impression- severity (cgi-s) were used to assess disease activity in patient groups. data analysis was performed using spss version 18. for statistical analysis, analysis of variance (anova), independent-sample t test, pearson correlation, and chi-square tests were utilized. p-values < 0.05 were considered statistically significant.results: the results showed that the mean of svd was significantly lower in mania and mixed bipolar patients compared to healthy subjects (p < 0.05). in addition, the number of subjects with svd ≥ 20 ng/ml was higher in the healthy group compared to the patient groups (p < 0.05). also, svd was negatively correlated with the cgi-s (r = -0.311; p = 0.028), ymrs (r = -0.464; p = 0.001), and hdrs (r = -0.393; p = 0.005) in the total patient subjects.conclusion: prevalence of low svd was considerably high in mania and mixed bipolar patients compared to healthy subjects. additionally, meaningful negative correlations were found between svd and disease activity-related variables including the hdrs, ymrs, and cgi-s.