Association of Il-8 (-251 A/T) Gene Polymorphism With Clinical Parameters and Chronic Periodontitis

Objective: to investigate the correlation between il-8 (-251 a/t) gene polymor-phism and susceptibility to chronic periodontitis as well as different clinical para-meters and severity of the condition in patients referred to dental school, shiraz university of medical sciences, shiraz, iran.materials and methods: in this randomized cross sectional study, 227 non-smoking patients with chronic periodontitis (test) and 40 healthy individuals (con-trol) were enrolled in this experiment and the following clinical parameters were employed in the study: periodontal pocket depth (ppd), clinical attachment level (cal) and bone loss (bl). all participants underwent the pcr (polyme-rase chain reaction) test to detect 251 a/t single nucleotide polymorphism of il8 gene.results: no significant correlation was perceived between different genotypes of il-8 and the severity of the periodontal condition (p= 0.164), neither did we detect any substantial association between different il-8 genotypes and the mean ppd (p=0.525), cal (p=0.151), bl (p=0.255), pi (p=0.087), bop (p=0.265) and the average number of teeth (p=0.931).conclusion: the results implied that there was no explicit correlation between 251 (a/t) il-8 gene polymorphism and the severity of the chronic periodontal disease or to the susceptibility to it.