Comparison of Interleukin-1β Levels in Gingival Crevicular Fluid and Peri-Implant Crevicular Fluid and Its Relationship with Clinical Indexes

Objective: interleukin-1β (il-1β ) is one of the most important cytokines which seems to have an important role in the inflammatory process in gingival and periimplant tissues. the aim of this split-mouth study was to investigate the relationship between the concentration of il-1β in gingival crevicular fluid (gcf) and peri-implant crevicular fluid (picf) and clinical parameters such as plaque index (pi), gingival index (gi), pocket depth (pd) and bone loss (bl). materials and methods: in 32 patients, picf and gcf samples of 41 implants and 41 contralateral teeth were collected and il-1β was determined by enzymelinked immunosorbent assay (elisa). pi, gi, pd and bl were recorded for each of the samples. result :the positive correlation between the level of il-1β and pi, gi, pd and bl in both groups was observed (p<0.0001). in similar conditions, the level of il- 1β was greatly higher in picf than gcf (75.26 pg/μl and 45.71 pg/μl , respectively) (p=0.001). conclusion: the findings of the present study indicated that the level of il-1β may be an important supplement to clinical findings in measuring the health status of gingival or peri-implant tissues.