determining the optimal thermodynamic conditions of ternary systems containing (co2, solvent, 5-fluorouracil) in the gas process

One of the methods to reduce the particle size is the gas method. in this method, the solute and antisolvent should be dissolved well in a solvent. but the solute is not dissolved in a solvent. the aim of studying this model is to determine the phase equilibrium and thermodynamic conditions of (co2, solvent, 5-fluorouracil) in the gas process. the solvents include methanol, ethanol, acetone, 1-propanol, and 1-butanol. the peng-robinson equation of state with a linear combination of vidal and michelsen mixing rules (pr-lcvm) was used for the thermodynamic modeling. the volume expansion of the binary system (co2, solvent) and ternary system (co2, solvent, 5-fluorouracil) at the temperature range of 313.15-319.15 k was investigated. the pmin values for the binary system were 66.7, 69.6, 60, 73.7, and 76.8 bar respectively for methanol, ethanol, acetone, 1-propanol, and 1-butanol at 313.15 k,. the pmin for the ternary system was also calculated. the comparison between the pmin values of binary and ternary systems showed that for a constant temperature and a certain solvent, the calculated minimum pressure in the ternary system was greater than the same in the binary system.