Phyllodes Tumor of the Breast: 307 Treated Cases, the Largest Mexican Experience At A Single Breast Disease Institution

Background: phyllodes tumor (pt) of the breast in hispanic patients is more frequently reported with large tumors and with more borderline/malignant subtypes compared with other populations. the objective of this study was to describe characteristics of patients with pt and to identify differences among subtypes in a mexican population. methods: a retrospective study was conducted on patients with pt. sociodemographic, histopathologic, and treatment characteristics were compared among subtypes, including only surgically treated cases due the complete surgicalspecimen study requirement for appropriate who classification. results: during 10 years, 346 pt were diagnosed; only 307 were included (305 patients), with a mean age of 41.7 yr. self-detected lump took place in 91.8%, usually discovered 6 months previously, with median tumor size of 4.5 cm. local wide excisions were done in 213 (69.8%) and mastectomies in 92 (30.1%). immediate breast reconstruction took place in 38% and oncoplastic procedures in 23%. pt were classified as benign in 222 (72.3%) cases, borderline in 50 (16.2%), and malignant in 35 (11.4%), with pathological tumor size of 4.2, 5.4, and 8.7 cm, respectively (p<0.001). patients with malignant pt were older (48 yr), with more diabetics (14.3%), less breastfeeding (37.1%), more smokers (17.1%), with more postmenopausal cases (42.9%), and older age at menopause (51.5 years) compared with the remaining subtypes (p<0.05). relapse occurred in 8.2% of patients with follow-up. conclusion: in comparison with other hispanic publications, these mexican patients had similar age, with smaller tumors, modestly higher benign pt, fewer malignant pt, and lower documented relapse cases.