The microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) genes among clinical isolates of staphylococcus aureus from hospitalized children

Background: isolates of staphylococcus aureus express a myriad of adhesive surface proteins that play important role in colonization of the bacteria on nasal and skin surfaces,beginning the process of pathogenesis. the aim of this study was to screen several of the microbial surface components recognizing adhesive matrix molecules (mscramms) genes among the isolate of s. aureus from hospitalized children. methods: a total of 22 s. aureus isolates were collected from hospitalized children in tehran from 2012 to 2013. detection of the meca and several adhesive surface proteins genes including clfa,b (encoding clumping factors a,b); fnba,b (encoding finronectin binding proteins a,b); fib (encoding fibrinogen binding protein); eno (encoding laminin binding protein); cna (encoding collagen binding protein); ebps (encoding elastin binding protein) and bbp (encoding bone sialo-protein binding protein),was performed by pcr. results: the clfab genes were detected among all the isolates. the prevalence of fnba,fnbb,fib,eno,cna,ebps and bbp was 63%,6%,50%,59%,82%,63%,9% and 0%,respectively. conclusion: the high prevalence of these genes is important for future plans in vaccine designation. mrsa and mssa isolates similarly can produce adhesive surface proteins for colonization. © iran j pathol. all rights reserved.