Frequency of Human Papillomavirus Genotypes 6, 11, 16, 18 and 31 in Paraffin-Embedded Tissue Samples of Invasive Breast Carcinoma, North-East of Iran

Background &objective: breast cancer is the most common female malignancy. detection of dna of human papillomaviruses (hpvs) in breast carcinomas suggests that the virus may play a role in the pathogenesis of this disease. the aim of this study was to evaluate the frequency of hpvs genotypes 6, 11, 16, 18 and 31 in paraffin-embedded tissue samples of invasive breast carcinomas. methods: three hundred and twenty six paraffin-embedded tissue samples of breast cancer were studied. pcr was performed using specific primers for hpv genotypes. results: of total 206 (63.2%) samples positive for beta-globin gene, 54 (26.2%) were hpv-positive and 152 (73.8%) were negative for hpv. distribution of hpv genotypes were as follows: 19 (25.7%) were positive for genotype 11, 5 (6.8%) were positive for genotype 6; and 2 cases (2.7%) were positive for both genotypes 6 and 11. samples were also screened for hpv genotypes 16, 18 and 31 but none was positive. conclusion: the current study confirmed the association of hpv and breast cancer. however, all samples were negative for high-risk hpv types 16, 18 and 31. how to cite this article: salehpour m, tayyebi meibodi n, teimourpour r, ghorani-azam a, sepahi s, rostami s, et al. frequency of human papillomavirus genotypes 6, 11, 16, 18 and 31 in paraffin-embedded tissue samples of invasive breast carcinoma, north-east of iran. iran j pathol. 2015;10(3):192-8.