Chemotherapy and Management of Locally Advanced Carcinoma Cervix

Background & objective: the present study was undertaken to ascertain the incidence of early, advancedcancer cervix and its recurrence and role of chemotherapy in locally advanced cancer cervix.material and methods: the present study was conducted in the departments of obstetrics &gynaecology, pathology and radiotherapy and the specimens examined in the department ofpathology of jawaharlal nehru medical college, aligarh muslim university, aligarh, india fromjuly 2009 to july 2010. one hundred histologically confirmed carcinoma cervix cases were dividedinto two groups. i: study group of cases receiving different types of chemotherapy and ii: controlgroup comprised of cases on pre and postoperative radiotherapy and surgery. patients were stagedand locally advanced inoperable cases (stage ib-iva) were given different types of chemotherapy.thereafter subjective and objective assessment was made according to world health organization(who) criteria of tumor response.results: majority of cases (60.0%) presented in stage iib of disease by international federationof gynecology and obstetrics (figo) classification. commonest symptom was postmenopausalvaginal bleeding, 70.0% cases. 68.0% & 56.0% cases showed complete response (cr) onchemotherapy and radiotherapy respectively. stage iib patients showed the best response withcr in 70.0% & partial response (pr) in 16.7% cases. colposcopic evaluation on 12 -18 monthsfollow up showed 08 to be disease free, with decrease in size of tumor.conclusion: chemotherapy is an effective mode of therapy and can be considered as an adjunct tosurgery or radiotherapy to improve the overall survival of cancer cervix patients.