evaluation the -174g>c genetic polymorphism of interleukin-6 in iranian patients with chronic lymphocytic leukemia

Background objective: interleukin-6 (il-6) is involved in inflammation and has a significant role in chronic lymphocytic leukemia (cll) progression. accordingly, il-6 level may increase in cll-affected patients compared to healthy individuals. the -174g>c single nucleotide polymorphism (snp) in il-6 promoter region has been related to differences in il-6 transcription. therefore, we investigated the possible association of il-6 polymorphism with cll.methods: we examined the -174g>c snp in il-6 gene and studied its possible relationship with cll in affected patients and in healthy controls using amplification refractory mutation system- polymerase chain reaction genotyping method.  il-6 plasma level was measured in both studied groups.results: according to the results, il-6 mean plasma concentration was increased significantly in the cll patients compared to the controls. however, 174g>c genotype of the il-6 gene was not associated with cll. furthermore, there were no significant differences in the distribution of allele and genotype frequencies between the cll-affected patients and the controls (p>0.05).conclusion: our study showed that -174g>c snp in promotor of il-6 gene could not be considered a risk factor for cll. larger prospective studies should be performed to confirm our results.