evaluation of gata3 and gcdfp15 expression in triple negative breast cancers

Background & objective: breast cancer is one of the most common cancers in the world. there are some different types of breast cancer and triple-negative breast cancer is the type in which no receptors for estrogen, progesterone, and human epidermal growth factor receptor-2 are expressed. identifying factors that can facilitate the diagnosis of triple-negative breast cancer is important. in this study, we decided to investigate the expression of gata3 and gcdfp15 genes in triple-negative breast cancers. methods: this is a retrospective descriptive-analytical study that was performed on 50 specimens of samples of triple-negative breast cancer. data including age and sex, tumor grade, tumor size, types of invasion, gata-3, and gcdfp-15 were assessed. results: the mean age of the patients was 48.3±14.17 years. of the total specimens, 46% were positive for gcdfp15 and 90% were positive for gata-3. the intensity of gata3 was evaluated and it was observed that 33(73.3%) of the cells were strongly stained and 12(26.7%) were weakly stained. there were no relationships between gata-3 and gcdfp-15 with tumor characteristics. conclusion: gata-3 and gcdfp-15 may serve as diagnostic markers for triple-negative breast cancers and gata-3 seems to be more reliable.