kindlin1 as a sex and location specific diagnostic marker in gastric cancer patients

Background objective: gastric cancer (gc) is considered one of the main reasons for cancer-related mortalities among iranians. kindlin-1 is an adhesion protein member of integrin-interacting proteins, regulating integrin activation through direct interaction with β-integrin. therefore, kindlin-1 can be involved in the regulation of cell proliferation and adhesion. in the present study, we assessed the possible role of kindlin-1 in gc progression and metastasis.methods:  kindlin1 messenger rna (mrna) expression was assessed in tumor tissues from 80 gc patients in comparison with normal tissues using real-time polymerase chain reaction (pcr).results: the levels of kindlin1 expressions were significantly correlated with sex (p=0.05) and tumor location (p=0.002). kindlin1 expression was also significantly associated with lymph node metastasis among the helicobacter pylori (hp)-negative cases (p=0.001). moreover, a significant association between age and kindlin1 expression was observed among the hp-positive cases (p=0.039).conclusion: in the present study, we introduced kindlin1 as a location-specific marker for cardia gastric carcinoma. moreover, it was observed that kindlin1 could be used as a sex-dependent diagnostic marker of gc patients.