mif and mmp-9 serum changes in type ii diabetes and non-diabetic subjects: a short communication

Background & objective: diabetes is a metabolic disease and is associated with failure of various organs. macrophage migration factor (mif) and matrix metalloproteinase (mmp-9) are two of the most important factors in the pathogenesis of diabetes. methods: in this descriptive-analytical study, 30 patients with type 2 diabetes mellitus from hamadan diabetes center were selected by convenience sampling. moreover, 30 healthy first-degree relatives and 30 unrelated non-diabetics, were examined for mmf and mmp-9 and their variations based on age, gender, body mass index (bmi) and hemoglobin a1c. results & conclusion: the mean and standard deviation of mif in diabetic patients, and relatives and non-relatives of diabetic patients were 592.87±78.19, 131.82±88.27 and 94.63±23.88, respectively (p<0.001). the mean and standard deviation of the mmp-9 in diabetic patients, and relatives and non-relatives of diabetic patients were 2570.64±2220.03, 918.57±650.08 and 629.09±288.32, respectively (p<0.001). mif and mmp-9 did not have a significant relationship with age, sex, duration of disease and bmi. however, we observed a direct and significant correlation between hemoglobin a1c and the level of mif and mmp-9 (p<0.001). in patients with type 2 diabetes, serum levels of mmp-9 and mif, consistent with hba1c, increase with no significant association with age, sex, bmi and duration of diabetes.