interdigitating dendritic cell tumor of submandibular lymph node: case report and literature review

Dendritic cells (dcs) are key arms of immune system, which act in antigen presenting processes, and are considered as a bridge between innate and adaptive immune responses. dcs are found in both lymphoid and non-lymphoid organs. they are called interdigitating dendritic cells (idcs) in secondary lymphoid organs. idcs lack lineage surface markers and are positive for s-100 and vimentin. idc sarcoma (idcs) is a very rare neoplasm, which mainly affects lymph nodes, though there are reports of extra-nodal involvement. idcs is thought to have poor prognosis. although there is no consensus on the treatment modalities, such options as radical surgery, chemotherapy, and radiotherapy are performed depending on severity and site of the lesion. in this study, we present a case of idcs in a 53-year-old male with a history of several skin lesions and prior diagnoses of basal cell carcinoma (bcc), squamous cell carcinoma (scc), and metatypical carcinoma (mtc).